HijackThis, a general homepage hijackers detector and remover. Initially based on the article Hijacked!, but expanded with almost a dozen other checks against hijacker tricks. It is continually updated to detect and remove new hijacks. It does not target specific programs/URLs, just the methods used by hijackers to force you onto their sites.
As a result, false positives are imminent and unless you are sure what you're doing, you should always consult with knowledgable folks (e.g. the forums) before deleting anything.
EditorsNote: Hijack This is for advanced users. If you are not familiar with running processes on your computer as well as anything ever installed that could tie into your web browser, it will not be much help to you. Thats ok, were here to help you!
CWShredder 1.50 updated, for removing the browser hijack, freeware.